2-Arachidonoylglycerol (2-AG)

This page is currently under construction!

This page should not be linked to on the site, but you may have stumbled across this page from a search engine.

2-Arachidonoylglycerol (2-AG) is an endocannabinoid that is of relevant interest in human reproductive biology

2-AG is an inhibitor of human CatSper, which results in impaired fertility when 2-AG is present in the sperm plasma membrane. The protein ABHD2 which is also present in the sperm plasma membrane is able to cleave 2-AG upon Progesterone binding to ABHD2. The products of the enzymatic hydrolysis, glycerol and arachidonic acid, do not inhibit CatSper, allowing for activation of the channel.


Image from Wikipedia

ABHD2 CatSper Progesterone